Two molecules--Hif-1alpha and Hif-2alpha--work together to stop the formation of leukemic stem cells in acute myeloid leukemia, according to a new study from the University of Edinburgh. "Our discovery that Hif-1alpha and Hif-2alpha molecules act together to stop leukemia development is a major milestone in our efforts to combat leukemia," said Professor Kamil R Kranc, Cancer Research UK Senior Fellow at the MRC Centre for Regenerative Medicine. "We now intend to harness this knowledge to develop curative therapies that eliminate leukemic stem cells, which are the underlying cause of AML." Release